Summary: The dynamic process by which nuclear RNAi engages a transcriptionally active target, before the repressive state is stably established, remains largely a mystery.Here, we found that the onset of exogenous dsRNA-induced nuclear RNAi in C.elegans is a transgenerational process, and it requires a putative histone methyltransferase (HMT), SET-

Abstract Background Mid-portion Achilles tendinopathy (AT) is a common overuse injury which can be difficult to successfully rehabilitate.Whilst peripherally directed treatment approaches that strengthen the Achilles tendon complex can be efficacious for some individuals, others will continue to experience long-standing pain and functional deficits

With the formation and popularity of the Internet of Things(IoT), the difficulty of protecting IoT infrastructure and smart devices from a few-shot of ever-changing malicious attacks has increased significantly.Traditional intrusion detection models in static mode cannot defend against intelligent attacks that change in real time and are good at re

Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis.Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris.Our aim was to verify th

Plain Language summary COVID-19 has affected the delivery of healthcare services globally.Antenatal care Yoga Leggings - AOP is one of the healthcare services that has been impacted on a global scale.Little is known about how antenatal care provision has changed in the Netherlands during the pandemic period.Our project focuses on examining the effe